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Transvaginal Mesh Side Effects

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Pelvic organ prolapse (POP), also known as female genital prolapse, is characterized by descent of female genital organs beyond their normal anatomical confines. The condition usually occurs when the pelvic floor collapses as a result of childbirth or heavy lifting which can tear soft tissues, i.e. herniating fascia membranes so that the vaginal wall collapses, resulting in cystocele, rectocele or both. Remediation typically involves dietary and lifestyle changes, physical therapy, or surgery.


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Types

anterior vaginal wall prolapse

Cystocele (bladder into vagina)

  • Urethrocele (urethra into vagina)
  • cystourethrocele (both bladder and urethra)
  • posterior vaginal wall prolapse
  • Enterocele (small intestine into vagina)
  • Rectocele (rectum into vagina)
  • apical vaginal prolapse
  • Uterine prolapse (uterus into vagina)
  • Vaginal vault prolapse (roof of vagina) - after hysterectomy

The term uterovaginal prolapse is sometimes defined as any or several of the above, and sometimes as uterine prolapse specifically.


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Grading

Pelvic organ prolapses are graded either via the Baden-Walker System, Shaw's System, or the Pelvic Organ Prolapse Quantification (POP-Q) System.

Shaw's System

Anterior wall

  • Upper 2/3 cystocele
  • Lower 1/3 urethrocele

Posterior wall

  • Upper 1/3 enterocele
  • Middle 1/3 rectocele
  • Lower 1/3 deficient perenium

Uterine prolapse

  • Grade 0 Normal position
  • Grade 1 descent into vagina not reaching introitus
  • Grade 2 descent up to the introitus
  • Grade 3 descent outside the introitus
  • Grade 4 Procidentia

Baden-Walker

POP-Q


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Management

Vaginal prolapses are treated according to the severity of symptoms. They can be treated:

  • With conservative measures (changes in diet and fitness, Kegel exercises, pelvic floor physical therapy.)
  • With a pessary, a rubber or silicon device fitted to the patient which is inserted into the vagina and may be retained for up to several months. Pessaries are a good choice of treatment for women who wish to maintain fertility, are poor surgical candidates, or who may not be able to attend physical therapy. Pessaries require a provider to fit the device, but most can be removed, cleaned, and replaced by the woman herself. Pessaries should be offered to women considering surgery as a non-surgical alternative.
  • With surgery (for example native tissue repair, biological graft repair, absorbable and non-absorbable mesh repair, colpopexy, colpocleisis). Surgery is used to treat symptoms such as bowel or urinary problems, pain, or a prolapse sensation. According to the Cochrane Collaboration review (2016) current evidence does not support the use of transvaginal surgical mesh repair compared with native tissue repair for anterior compartment prolapse owing to increased morbidity. Safety and efficacy of many newer meshes is unknown. The use of a transvaginal mesh in treating vaginal prolapses is associated with side effects including pain, infection, and organ perforation. According to the FDA, serious complications are "not rare." A number of class action lawsuits have been filed and settled against several manufacturers of TVM devices.

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Epidemiology

Genital prolapse occurs in about 316 million women worldwide as of 2010 (9.3% of all females).

Source of the article : Wikipedia



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